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Signal-coupling technology and premium surface-mounted components ensure a more reliable connection and better throughput. Additionally, electrostatically-guarded and surge-protected components ESD Guards allow for 1. Exclusive GameFirst III prioritizes game-related packets and allocates more bandwidth to games, eliminating laggy gameplay, streaming stutters and file-sharing slowdown — so you'll always be the frontrunner.Friday, December 23, Will funder mandates and author attitudes kill embargoes?
Geochemical Transactions -- starting over OA. With volume 7, the editorial board is trying a new tact. Officially the move is effective on 1 January An announcement of the purchase of all of the backfiles and an editorial on the new vision for the journal.
Moving Geochemical Transactions forward as an open access journal. Geochemical Transactions OA science for lay readers will help fight ID.Most resilient zodiac sign
Welcome to the blogosphere, Mike! Connotea developer recognized. German OA resources in psychology. OA helps respond to disasters. Exactly right.Flexible workflow 1909
But note that this is just a special case of a more general principle: the more knowledge matters, the more OA to that knowledge matters.
Relief information is to disasters what general research literature is the whole range of human problems. Google is changing medicine.
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PS: How are search advances, from Google and others, changing your field? More on the OA preprint repository in classics. Q: Which is the more important function of PSWP in your view: to enable authors to solicit comments prior to submitting articles to a journal, or to increase the visibility of research being done by the Princeton and Stanford departments of classics? A: I regard soliciting comments as more important than publicity per se. I am perfectly happy to have the work of our two faculties receive extra attention, but that is not my main concern.
But I must say that a classics repository for all classicists would be more useful than one limited to faculty from two distinguished departments. A: Sure he does. Our initiative is constrained by two considerations: quality control and resources Q: Do you envisage classics departments from other universities being invited to deposit their papers at your site in future?
A: We have left that as an open question The long-term answer might be for a professional association to become the primary site for hosting classics WPs Q: Suber also commented "[A]n OAI-compliant repository would be more useful than a non-compliant repository. A: This is beyond my expertise level. Q: So is OA an inherently good thing for the humanities or just something that some researchers may find interesting to provide? A: By calling something an inherent rather than an instrumental good, you set the bar pretty high.
I tend to think of OA as an instrumental good, but it may be understood as an intrinsic aspect of inherent goods freedom, democracy. OA is in this sense an instrument for delivering something that may be of inherent valueThis protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factoruntil an injury that damages blood vessels occurs.
The active protein sometimes written as coagulation factor VIIIa interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot. The factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoproteinisoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex.
This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc.Tsp matlab
This binding domain is essential for coagulant activity. People with high levels of factor VIII are at increased risk for deep vein thrombosis and pulmonary embolism. There is a formulation as a medication that is on the WHO Model List of Essential Medicinesthe most important medications needed in a basic health system. The gene for factor VIII presents an interesting primary structure, as another gene is embedded in one of its introns.
The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin. The protein is now divided to a heavy chain, consisting of the A1-A2 domains, and a light chain, consisting of the A3-C1-C2 domains.
Both form non-covalently a complex in a calcium-dependent manner. This complex is the pro-coagulant factor VIIIa. FVIII is a glycoprotein pro cofactor. Although the primary site of release in humans is ambiguous, it is synthesized and released into the bloodstream by the vascular, glomerular, and tubular endotheliumand the sinusoidal cells of the liver. In the blood, it mainly circulates in a stable noncovalent complex with von Willebrand factor.
Upon activation by thrombin factor IIait dissociates from the complex to interact with factor IXa in the coagulation cascade.
It is a cofactor to factor IXa in the activation of factor Xwhich, in turn, with its cofactor factor Vaactivates more thrombin.
Thrombin cleaves fibrinogen into fibrin which polymerizes and crosslinks using factor XIII into a blood clot. No longer protected by vWF, activated FVIII is proteolytically inactivated in the process most prominently by activated protein C and factor IXa and quickly cleared from the blood stream.
Factor VIII is not affected by liver disease. In fact, levels usually are elevated in such instances. Antibody formation to factor VIII can also be a major concern for patients receiving therapy against bleeding; the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself.
In the s, some pharmaceutical companies such as Baxter International and Bayer sparked controversy by continuing to sell contaminated factor VIII after new heat-treated versions were available. In the early s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. Factor VIII was first discovered inbut it was not until that its purification by Edward Tuddenham and coworkers led to the molecular identification of the protein.
From Wikipedia, the free encyclopedia.
This article is about the protein. Main article: Contaminated haemophilia blood products.Even after the newly-formed Church of England granted Henry VIII his annulment, Catherine of Aragon remained faithful to her former spouse, in part to secure the interests of their daughter, the future Mary I.
Considered by many to be among the most handsome rulers of his era, Henry VIII was always larger-than-life—he was well over 6 feet tall. But he only grew in girth after a jousting accident left him less and less able to exercise.
In truth, though, Henry VIII was by far the bloodiest Tudor ruler, ordering tens of thousands of executions during the tumult of the English Reformation.
Years before his death, Henry VIII made plans to build a monumental tomb for himself and Jane Seymour, his favorite queen and the mother of his only surviving male heir.
Henry confiscated a black marble sarcophagus originally intended for the powerful churchman Cardinal Wolsey to be used at the center of the tomb, but during the tumultuous years after his death inthe monument was never completed.
Instead, Henry and Jane were left to rest in peace in what were supposed to be temporary lodgings in a crypt at Windsor Castle. But if you see something that doesn't look right, click here to contact us!
Twice a week we compile our most fascinating features and deliver them straight to you. This Day In History. He wrote a beloved popular song—but not the one you think. He was only obese during the last years of his life. Henry ordered as many as 72, executions during his reign.Table of contents: 1. Introduction 2.افضل عطور للرجال قدميها هدية من avon,oriflame,yves rocher
The purposes of Hornbostel-Sachs 3. The introduction to Hornbostel-Sachs 4. Governance of Hornbostel-Sachs 5. Examples of Hornbostel-Sachs used in bibliographic classification: 5.
Bliss Classification; 5. DDC early editions; 5. Flexible Classification; 5. UDC; 5. DDC Phoenix Schedule and modern editions 6. This classification system was originally designed for musical instruments and books about instruments, and was first published in German in The position of Hornbostel-Sachs in the history and development of instrument classification is explored.
This is followed by a detailed analysis of the mechanics of the scheme, including its decimal notation, the influential broad categories of the scheme, its warrant, and its typographical layout.
The version history of the scheme is outlined and the relationships between versions is visualised, including its translations, the introduction of the electrophones category, and the MIMO version designed for a digital environment. The reception of Hornbostel-Sachs is analysed, and its usage, criticism and impact are all considered. As well as dominating organological research and practice for over a century, it is shown that Hornbostel-Sachs also had a significant influence on the bibliographic classification of music.
In fact, the scheme has played a significant role in the development of the domain in which it was created: organology, which is the study of musical instruments. First published in German inHornbostel-Sachs has seen modifications and changes throughout its history, but the scheme remains part of contemporary musical instrument discourse and practice. While designed primarily to classify physical collections of musical instruments, Hornbostel-Sachs was redesigned in the s as an ordering system for digital information about instruments.
Its reach spreads throughout organology, and arguably Hornbostel-Sachs is sometimes seen as being seen as synonymous with instrument classification.
The article starts with an overview of the origins and history of Hornbostel-Sachs, placing the scheme within the context of general developments of musical instrument classification and discussing the original purposes of the scheme.
Next, the mechanics of the scheme are explored, including its basic structure, atypical notation, warrant, and typographical layouts, among other areas.He famously married a series of six wives in his search for political alliance, marital bliss and a healthy male heir.
His desire to annul his first marriage without papal approval led to the creation of a separate Church of England. While his older brother Arthur was being prepared for the throne, Henry was steered toward a church career, with a broad education in theology, music, languages, poetry and sports. Arthur had been betrothed since age 2 to Catherine of Aragon, the daughter of the Spanish rulers Ferdinand and Isabella, and in November of the teenage couple were married.
Months later, Arthur died of a sudden illness.
Over the next 15 years, while Henry fought three wars with France, Catherine bore him three sons and three daughters, all but one of whom died in infancy. The sole survivor was Mary later Mary Iborn in Henry was an active king in those years, keeping a festive court, hunting, jousting, writing and playing music. But the lack of a male heir—especially after he fathered a healthy illegitimate son, Henry FitzRoy, in —gnawed at the king.
The king decided to seek a papal annulment that would free him to remarry. Wolsey was forced from power for his failure and died in awaiting trial for treason. In Henry and Anne Boleyn were married, and their daughter Elizabeth was born.
Mary was declared illegitimate and Elizabeth named his heir. In January of Henry was unhorsed and injured during a jousting tournament. When news of his accident reached the pregnant Anne, she miscarried, delivering a stillborn son. Henry then spurned her, turning his affections to another woman of his court, Jane Seymour.
Within six months he had executed Anne for treason and incest and married Jane, who quickly gave him a son the future Edward VI but died two weeks later. Anne of Cleves was a political bride, chosen to cement an alliance with her brother, the ruler of a Protestant duchy in Germany.
The marriage only lasted a few days before Henry had it annulled. He then married Catherine Howard, but two years later she too was beheaded for treason and adultery. In the last years of his reign Henry grew moody, obese and suspicious, hobbled by personal intrigues and by the persistent leg wound from his jousting injury. His final marriage, to the widow Catherine Parr insaw his reconciliation with Mary and Elizabeth, who were restored to the line of succession. His 9-year-old son Edward VI succeeded him as king but died six years later.
But if you see something that doesn't look right, click here to contact us! Subscribe for fascinating stories connecting the past to the present. She sought to return England to the Catholic One of the most renowned kings in English history, Henry V led two successful invasions of France, cheering his outnumbered troops to victory at the Battle of Agincourt and eventually securing full control of the French throne.
His portrayal in three of The plot was organized by Robert Catesby c. Catesby and Eleanor of Aquitaine was one of the most powerful and influential figures of the Middle Ages. Inheriting a vast estate at the age of 15 made her the most sought-after bride of her generation.
She would eventually become the queen of France, the queen of England and But it's the monarch's tumultuous romantic life, rather than his politics, that have kept him in the spotlight. Henry VIII is best knownGo to the content. Move to the navigation Go to the site search Go to the menu Contacts Accessibility. Scenari di educazione ai media con un progetto territoriale. From the Public Library to the Multimedia Public Library: perspectives of education to the media culture with a territorial project.
The first part of this Doctorial Dissertation, contained in the first chapter, aims basically at contextualizing the object of the research.
This analysis has the purpose of underlying the contemporary necessity for a transformation, also in our country, of the Public Library in Multimedia Public Library, according to the latest social requirements for communication technology update, which means also cultural and educational update.
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This hoped for change, should not be a mere change of name, but the possibility of a real enrichment of culture and communication services. In Italy we are far from accomplishing this changing, which is not true for other so called developed countries.
In the first place because the French and the Italian systems were quite similar in their organisational features and typology, before the radical modernisation of the Public Library System in France, accomplished between the end of the '70 and the beginning of the '80 in the last century, following the project of the Multimedia Public Library.Convert lat long to x y z coordinates
In the second place because, beginning from a new name to end with the achievement of concrete results, the "French experience" is an innovative national project carried out homogeneously, which could be envisaged as a model, as a cultural and educational strategy to be followed also in Italy. In the context of this research, the enrichment of these services has to be seen mainly as an enlargement of the possibility of fruition of audiovisual and interactive media on and off-line, and as the completion of educational requirements.
All this aims at developing people's technical know-how and multimedia skills, in order to allow them to be able to "read" in full awareness, to be able to connect oneself and to live in the contemporary democratic society. To become accustomed to the technological tools and to the multimedia languages is essential to concretely test these skills, which are the starting step to multimedia communication.
The object of this research is therefore at first analysed from a "problem solving" point of view, in different type of social contexts: institutional, cultural, operational and statistic. The devising of these contexts aims at defining key words as "media", "multimedia", and "multimedia public library" that will be used frequently in the treatise.
It has moreover the purpose of viewing the main topic, that is the transformation of the Library in Multimedia Public Library, in its possibilities of cultural and educational development, with the help of the meagre and often too specialised cultural debate on this particular subject.
The second part of the Dissertation, contained in the second chapter, is meant to be the real core of this research. Here is a deep historical and critical analysis of the theoretical researches and of the practical outcomes related to the concept of Multimedia Library developed in Italy, or in some ways connected to the national territory.
This analysis is being carried out thanks to the researches and experimentation of the late Seventies developed in connection and inside the University of Padua Audiovisual Laboratory, Professorship of methodology and didactics of audiovisual media, Faculty of Education. On the ground of contemporary experiences the accomplishment of the national project named "Mediateca " has been analysed, together with the debate that aroused from it in the recent congress "Public libraries: the conversation of media" in May The treatise analyses the different experiences through a wide and deep bibliographical and geographical research, following as much as possible a chronological sequence, and arriving till to-day in the investigation of theories, projects, experimentations and outcomes.
Seen as a whole, the results of this research can draw the outline of a new perspective on the idea of Multimedia Library: the suggestions and information about methods, theories and fulfilments, it gives could form the platform for the concrete accomplishment of the transformation of the traditional public libraries in multimedia public libraries. The third part of the Dissertation is a brief but complete project for the creation of a real multimedia library.
The project is located in Padua, in order to be easily applied to the concrete transformation of the Padua Municipal Public Library in a Multimedia Public Library, situated in the restored complex of the former Court of Justice. My role as the President of the 4th South - East District of Padua, a task I undertook a few years ago, gave me the possibility to acquire a specific expertise on this matter, being also the representative of the districts in the Culture Commission of the Municipality of Padua, and the person in charge for the cultural activities for the political party of the former City Councillor for Culture in the city of Padua, and having above all the assignment of evaluating and investigating the projects of fulfilment of this cultural transformation.
This project is aware of the concrete, many-sided problems and expectations of the city administration, considered in the whole of its different politicians, managers and professionals, and tries to fulfil them as much as possible, having always in mind the key idea of the Public Multimedia Library.
This is why the project hypothesis is founded on the results obtained from the deep scientific analysis carried out in the second chapter of the Dissertation.
A survey, answered in the form of a questionnaire addressed to the municipal employees of the city public library system, is also part of the project. This survey aims at understanding the psychological attitude of these professional operators, their skills, know-how and abilities.
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